Diazinon - Toxicity Data: Oral TDLO (human): 214 mg/kg; Oral LD50 (rat): 66 mg/kg; The reason that EPA does not accept this type of human study is clear: in order to determine the dose that produces no effect, test animals, in this case humans, must be exposed to doses of the pesticide that cause toxic effects. Diazinon is an insecticide, a product used to kill or control bugs. A no effect level is the stepping stone from which the agency determines a safe exposure dose. Diazinon can cause cholinesterase inhibition in humans; that is, it can overstimulate the nervous system causing nausea, dizziness, confusion, and at very high exposures (e.g. July 1994 – ; Preliminary Human Pesticide Exposure Assessment (For Use on Residential Turf and Soil) (PDF) Other Documents. This is for information only and not for use in the … Risk Characterization Documents (RCDs) estimate the nature and likelihood of adverse health effects in humans who may be exposed to pesticides. diazinon’s toxicological effects stem from its inhibition of AChE. Risks The phase-out of Diazinon pest products actually began in 1988, after large quantities of mass bird kills were linked to Diazinon treatments in large open areas. Toxicological Information The toxicological effects of this product have not been thoroughly studied. It is associated with an increased risk of brain cancer in children and the … Apart from kidney and liver where diazinon metabolites predominated, most of the radioactivity (56-85%) present in these tissues was associated with unchanged diazinon (Capps, 1990 with an amendment by Carlin, 1994). Poisoning can occur if you swallow diazinon. The EPA found Diazinon highly toxic to birds and banned its use in such areas as golf courses. Why Banned Toxic Substances Diazinon & Dursban are Still In Use Today: An Interview with Environment by www.SixWise.com. Diazinon and other organophosphates inhibit numer-ous enzymes with molecular structures that are similar to AChE. 2.1.2.4. Diazinon SAFETY DATA SHEET 11.1 CAS # Hazardous Components (Chemical Name) NTP Section 11. December 2010 – Report on Air Monitoring of an Orchard Application of Diazinon in Glenn County during January 2010 Body systems affected by diazinon. Diazinon exhibits high acute toxicity to a wide variety of animals, leading to a wide range of sublethal biochemical effects, damage to specific target organs and tissues, cytotoxic and genotoxic effects, reproductive damage, and adverse ecological impacts. Health Effects. Tissue distribution In male Yok:ddY outbred strain mice, kidney, liver and brain concentrations of diazinon after accidents or major spills) respiratory paralysis and death. Likewise, diazinon highly toxic to birds, mammals and other beneficial animals such as honeybees and earthworms. Its biological fate is complex, mediated largely by diverse metabolic mechanisms. EPA’s own data show that diazinon is a potent nerve poison responsible for numerous human poisonings and deaths. After the Environmental Protection Agency (EPA) banned the pesticides diazinon and dursban because of health concerns for humans and wildlife, they continued to be used until stockpiles ran out. For example, an enzyme involved in the metabolism of the amino acid tryptophan is strongly in-hibited by diazinon … Diazinon is particularly detrimental to both the respiratory tract and the central nervous system. Diazinon is readily absorbed by inhalation, ingestion and skin penetration. Diazinon is also detrimental to aquatic plants, algae and sediment residing organisms. Birds and banned its Use in such areas as golf courses birds and banned its Use in areas! 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